Seth Godin has some suggestions in his book "Free Prize Inside" to make a great presentation using Power Point.
1. No more than six words on a slide. Ever. There is no presentation so complex that this rule needs to be broken.
2. No cheesy images. Use professional stock photo images.
3. No dissolves, spins or other transitions.
4. Sound effects can be used a few times per presentation, but never use the sound effects that are built into the program. Instead, rip sounds and music from CDs and leverage the Proustian effect this can have. If people start bouncing up and down to the Grateful Dead, you've kept them from falling asleep, and you've reminded them that this isn't a typical meeting you're running.
5. Don't hand out printouts of your slides. They don't work without you there.